This is a list of airlines currently operating in South Africa
| AIRLINE | ICAO | IATA | CALLSIGN | COMMENCED OPERATIONS |
|---|---|---|---|---|
| 1Time | RNX | T6 | NEXTTIME | |
| Airlink | LNK | 4Z | LINK | |
| AirQuarius Aviation | AQU | - | QUARIUS | |
| Allegiance Air | ANK | - | AIR ALLEGIANCE | |
| CEM Air | - | - | ||
| Civair | CIW | 2I | CIVFLIGHT | |
| Comair | CAW | MN | COMMERCIAL | |
| Command Airways (South Africa) | CAH | CT | COMMAND | 1977 |
| Egoli Air | 1996 | |||
| Federal Air | FDR | - | FEDAIR | |
| Global Aviation | GBB | QG | GLOBE | 2001 |
| Interair South Africa | ILN | D6 | INLINE | |
| King Air Charter | - | - | - | |
| Kulula.com | CAW | MN | COMAIR | |
| Mango | MNO | JE | TULCA | |
| National Airways | NTN | YJ | NATCHAIR | |
| Naturelink Aviation | NRK | - | NATURELINK | |
| Norse Air | NRX | - | NORSE AIR | |
| Phoebus Apollo Aviation | PHB | PE | PHOEBUS | 1995 |
| Rovos Air | VOS | - | ROVOS | |
| Safair | SFR | FA | CARGO | |
| Solenta Aviation | 2002 | |||
| South African Airways | SAA | SA | SPRINGBOK | |
| South African Express | EXY | YB | EXPRESSWAYS | |
| Star Air Cargo | BRH | BRIGHTSTAR | ||
| Velvet Sky (airline) | VEL | VZ | VELVET | 2009 |
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